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Research Articles Issue 2 · 2021 · pp. 157–172 · Issue page

CLINICAL AND HISTOPATHOLOGICAL CORRELATIONS IN BOWEN'S DISEASE

AL
Alina Maria VÎLCEA1
LO
Loredana Elena STOICA2
TI
Tiberiu Ștefăniță ȚENEA COJAN3
CL
Claudia Valentina GEORGESCU4
DA
Daniel-Cristian PÎRVU5
BI
Bianca Cătălina ANDREIANA6
CE
Cecil Sorin MIREA7
1 Lecturer, Ph. D., University of Medicine and Pharmacy of Craiova, Romania, Department of Dermatology
2 Associate Professor, University of Medicine and Pharmacy of Craiova, Romania, Department of Dermatology
3 Associate Professor, Ph. D., University of Medicine and Pharmacy of Craiova, Romania, Department of Surgery
4 Ph. D., Clinical Hospital of Emergency Craiova, Department of Pathology
5 Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
6 Assistant Professor, Ph. D., University of Medicine and Pharmacy of Craiova, Romania, Department of Pathology
7 Associate Professor, Ph. D., University of Medicine and Pharmacy of Craiova, Romania, Department of
Corresponding author: [email protected]
DOI https://doi.org/10.38173/RST.2021.22.2.15:157-172
Received 22 October 2021
Revised 3 November 2021
Accepted 12 November 2021
Available Online 15 November 2021
Abstract
BOWEN'S DISEASE (BD) IS AN IN SITU, PREINVASIVE CANCER WITH POTENTIAL FOR PROGRESSION IN SQUAMOUS CELL CARCINOMA (SCC), BEING CLINICALLY CONSIDERED A PRECANCER WITH A HIGH POTENTIAL FOR MALIGNANCY. THE AIMS OF THE STUDY WERE TO ASSES S THE CLINICAL, HISTOLOGICAL, AND EVOLUTIONARY ASPECTS OF THE BOWEN'S DISEASE AND INVASIVE BOWEN DISEASE. THE STUDIED GROUP COMPRISES 50 PATIENTS DIAGNOSED WITH BOWEN DISEASE OR INVASIVE BD, HOSPITALIZED IN THE DERMATOLOGY CLINIC OF EMERGENCY COUNTY HOSPIT AL OF CRAIOVA, BETWEEN 2010 AND MARCH 2021. THERE WERE 18 MALES AND 32 FEMALES, AGED 30 TO 85 YEARS, 66% OF THE PATIENTS BEING FROM THE URBAN ENVIRONMENT. THE MOST FREQUENT LOCALIZATION OF BD WAS AT THE LEVEL OF THE LIMBS (52%), ON PHOTOEXPOSED AREAS. IN 92% OF CASES, WE NOTICED CLINICAL ASPECT OF BD WITH SINGLE LESIONS AND THE TYPICAL FORM WAS PREDOMINANCE (80%). THE PATHOLOGY DIAGNOSED 41 BD AND 9 INVASIVE BD (SQUAMOUS CELL CARCINOMA). PRESUMPTIVE CLINICAL DIAGNOSIS IN 31 CASES (57.40%), WAS CONFIRMED BY HISTOPATHOLOGICAL EXAMINATION. THE CORRELATION OF CLINICAL, HISTOPATHOLOGICAL DATA LEAD TO AN ACCURATE DIAGNOSIS OF BD. BOWEN'S DISEASE, ALONG WITH OTHER KERATINOCYTIC PRECANCERS, BEING A STRONG PREDICTOR OF THE RISK OF DEVELOPING SKIN CARCINOMAS AND MELA NOMA, REQUIRING A PROMPT THERAPEUTIC ATTITUDE AND CAREFUL MONITORING.
Keywords
BOWEN DISEASE SQUAMOUS CELL CARCINOMA EPIDEMIOLOGY
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