Research Articles Supplement 1 · 2020 · pp. 55–65 · Issue page

MATERNAL AND FETAL COMPLICATIONS OF GESTATIONAL DIABETES- REVIEW

EL
AN
AN
IU
FE
CO
1 “N. Paulescu”National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest
2 “N. Paulescu”National Institu te of Diabetes, Nutrition and Metabolic Di seases, Bucharest; University of Medicine and Pharmacy “Carol Davila”, Bucharest
3 “N. Paulescu”National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest
4 University of Medicine and Pharmacy “Carol Davila”, Bucharest; “Dr I Cantacuzino” Hospital Bucharest
5 “N. Simionescu” Institute of Cellular Biology and Pathology, Romania
6 “N. Paulescu”National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest; University of Medicine and Pharmacy “Carol Davila”, Bucharest
Received 07 March 2020
Revised -
Accepted 04 April 2020
Available Online 02 June 2020
GESTATIONAL DIABETES MELLITUS (GDM) IS A COMMON MEDICAL COMPLICATIONS OF PREGNANCY, WITH IMPORTANT CONSEQUENCES FOR MOTHER AND CHILD. IN RECENT YEARS, STUDIES HAVE BEEN FOCUSED ON COMPLICATIONS OF GDM DUE TO THE TRANSGENERATIONAL VICIOUS CIRCLE OF CARDIOMETABOLIC DISEASES THAT THIS DIAGNOSE GENERATES. NUMEROUS STUDIES ANALIZED THE ROLE OF MATERNAL HYPERGLYCEMIA IN THE OCCURRENCE OF THESE COMPLICATIONS AIMING TO NORMALIZING MATERNAL BLOOD GLUCOSE VALUES AND REDUCE THE ASSOCIATED COMPLICATIONS. DESPI TE TREATMENT OF GDM, INCREASED RATES OF ADVERSE NEONATAL OUTCOMES PERSIST. THE AIM OF THIS REVIEW IS TO DISCUSS CURRENT EVIDENCE ABOUT THE IMPORTANCE OF GDM, MATERNAL AND FETAL SHORT TERM RESPECTIVELY LONG TERM COMPLICATIONS.
GESTATIONAL DIABET ES COMPLICATIONS CLINICAL CARE OUTCOMES
The body of this article is intentionally hidden on the public page. Please use the PDF reader or the PDF download for the complete text.
[1]
Fraser A, Lawlor DA (2014) Long-term health outcomes in offspring born to women with diabetes in pregnancy. Curr Diab Rep 14:489
[2]
Clausen TD, Mathiesen ER, Hansen T et al (2008 ) High prevalence of type 2 diabetes and pre - diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia. Diabetes Care 31:340–346
[3]
Clausen TD, Mathiesen ER, Hansen T et a l (2009) Overweight and the metabolic syndrome in adult offspring of women with diettreated gestational diabetes mellitus or type 1 diabetes. J Clin Endocrinol Metab 94:2464–2470
[4]
Retnakaran R, Qi Y, Connelly PW, Sermer M, Zinnman B, Hanely AJ . Glucose intolerance in pregnancy and risk of metabolic syndrome in young women. J Clin Endocrinol Metab. 2010;95:670– 677.
[5]
Sullivan SD, Umans JG, Ratner R . Gestational diabetes; implications for cardiovascular health. Curr Diab Rep. 2011 e-pub (10-27-2011)
[6]
Retnakaran R, Shah BR. Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study. CMAJ. 2009;181:371–376.
[7]
Silverman BL, Green OC, Cho NH, Winter RJ, Ogata ES, Richards GE, Metzger BE. Long-term prospective evaluation of offspring of diabetic mothers. Diabetes. 1991;40(Suppl 2):S121–S125.
[8]
Hillier TA, Pedula KL, Schmidt MM, Mullen JA, Charles MA, Pettitt DJ . Childhood obesity and metabolic imprinting: the ongoin g effects of maternal hyperglycemia. Diabetes Care. 2007;30:2287– 2292.
[9]
Dabelea D, Mayer -Davis EJ, Lamichhane AP, D'Agostino RB, Liese AD, Vehik KS, Narayan KM, Zeitler P, Hamman RF. Association of in trauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH case-control study. Diabetes Care. 2008;31:1422–1426.
[10]
Whitaker RC, Pepe MS, Seidel KD, Wright JA, Knopp RH . Gestational diabetes and the risk of offspring obesity. Pediatrics. 1998;101:e9:1–e9:7.
[11]
Catalano PM, Farre ll K, Thomas A, Houston -Presley L, Mencin P, de Mouzon SH, Amini SB. Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr. 2009;90:1303–1313.
[12]
Silverman BL, Rizzo TA, Cho NH, Metzger BE. Long -term effects of the intraut erine environment. Diabetes Care. 1998;21(Suppl 2):B142–B149.
[13]
Gillman MW, Oakey H, Baghurst PA, Volkmer RE, Robinson JS, Crowther CA . Effect of treatment of gestational diabetes on obesity in the next generation. Diabetes Care. 2010;33:964–968.
[14]
Rowan JA, Hague WM, Gao W, Battin MR, Moore PM MiG Trial Investigators. Metformin versus insulin for treatment of gestational diabetes. N Engl J Med. 2008;358:2003–2015.
[15]
Kim C, Newton KM, Knopp RH . Gestational diabetes and the incidence of type 2 diabetes. Diabetes Care. 2002;25:1862–1868.
[16]
Peters RK, Kjos SL, Xiang A, Buchanan TA. Long-term diabetogenic effect of a single pregnancy in women with prior gestational diabetes mellitus. Lancet. 1996;347:227–230.
[17]
HAPO Study Cooperative Research Group. Hyperglycemia a nd Adverse Pregnancy Outcome (HAPO) study: Preeclampsia. Am J Obstet Gynecol. 2010;202(3):255.e251–e257.
[18]
Ferrara A, Weiss N, Hedderson M, et al. Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia, and hyperbilirubinaemia. Diabetologia. 2007;50(2):298–306.
[19]
Catalano P, Kirwan J, Haugel -de Mouzon S, King J . Gestational diab etes and insulin resistance: Role in short - and long -term implications for mother and fetus. J Nutr. 2003;133(5 Suppl 2):S1674 – S1683.
[20]
Boney C, Verma A, Tucker R, Vohr B. Metabolic syndrome in childhood: Association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115(3):e290–e296.
[21]
Bellamy L, Casas J, Hingorani A, Williams D . Type 2 diabetes mellitus after gestational diabetes: A systematic review and meta-analysis. Lancet. 2009;373(9677):1773–1779.
[22]
Carr D, Utzsch neider K, Hull R, et al. Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of Type 2 diabetes. Diabetes Care. 2006;29(9):2078–2083.
[23]
Shah B, Retnakaran R, Booth G. Increased risk of cardiovascular disease in young women following gestational diabetes. Diabetes Care. 2008;31(8):1668–1669.