VITAMIN D AND ITS RELATIONSHIP WITH CARDIOVASCULAR DISEASES
Corresponding author:
[email protected]
Received
17 February 2020
Revised
No
Accepted
12 March 2020
Available Online
15 March 2020
Abstract
VITAMIN D DEFICIENCY HAS BEEN ASSOCIATED WI TH DISEASES SUCH AS RICKETS, OSTEOMALACIA, OSTEOPOROSIS, SKIN DISEASES AND CARDIOVASCULAR DISEASE. VITAMIN D DEFICIENCY IS ASSOCIATED WITH INCREASED INFLAMMATION, INCREASED EXPRESSION OF INFLAMMATORY CYTO KINES, ENDOTHELIAL CELLS AND DYSFU NCTION OF VASCULAR SMOOTH MUSCLE CELLS AND DECREASED VDR EXPRESSION AND ACTIVITY, WHICH MAY LEAD TO THE DEVELOPMENT OF VASCULAR DISEASES, SUCH AS ATHEROSCLEROSIS, ANEURYSMS, VASCULAR CALCIFICATIONS, AND ARTERIAL HYPERTENSI ON. ALTHOUGH THERE IS EVIDENCE THA T VITAMIN D DEFICI ENCY IS ASSOCIATED WITH CARDIOVASCULAR DISEASE, A CAUSAL RELATIONSHIP HAS NOT BEEN IDENTIFIED YET.
Keywords
VITAMIN D DEFICIENCY
ATHEROSCLEROSIS
CARDIOVASCULAR DISEASE
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References
[1]
Holick, M.F. Vitamin D deficiency. N Engl J Med. 2007;357(3): 266–281.
[2]
Miricescu, D., Totan , A., Stanescu , A.M.A., Stanescu, I.I., Stefani, C., Greabu, M . Vitamin D deficiency and insulin resistance. Practica Medicala 2019;14,3(67): 227-232.
[3]
Roth, G.A., Johnson, C., Abajobir, A., et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70: 1–25.
[4]
Tousoulis, D., Psar ros, C., Demosthenous , M., et al . Innate and adaptive inflammation as a therapeutic target in vascular disease: the emerging role of st atins. J Am Coll Cardiol. 2014; 63: 2491– 2502.
[5]
Bejan, G.C., Stanescu, A.M.A., Ghilencea, N.L., Matei, D. Analiza actuala a aspectelor terapeutice moderne i n tratamentul HTA si al comorbiditat ilor asociate. Revista Medicala Romana 2018;LXV(2):102-107.
[6]
Gheorghe, G., Pantea Stoian, A., Gaman, M.A., Socea, B., Neagu, T.P., Stanescu, A.M.A., Bratu, O.G., Mischianu, D.L.D., Sucevea nu, A.I., Diaconu, C.C . The benefits and risks of antioxidant treatment in liver diseases. Rev Chim (Bucharest). 2019;70(2): 651-655.
[7]
Plotogea, O., Ilie, M., Sandru, V., Chiotoroiu, A., Bratu, O., Diaconu, C . Cardiovascular and metabolic consequences of liver transplantation: a review. Medicina (Kaunas). 2019;55(8). pii: E489.
[8]
Surcel, M., Munteanu, A.N., Huica, R.I., Isvoranu, G., Pirvu, I.R., Constantin, C., Bratu, O., Caruntu, C., Zaharescu, I., Sima, L., Costache, M., Neagu, M . Reinforcing involvement of NK cells in psoriasiform dermatitis animal model. Experimental And Therapeutic Medicine. 2019;18: 4956 - 4966.
[9]
Rocha, V.Z., Libby, P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. 2009;6: 399–409.
[10]
Wadhwa, B., Relhan, V., Goel, K., et al. Vitamin D and skin diseases: A review. Indian J Dermatol Venereol Leprol. 2015;81(4): 344–355.
[11]
Stanescu, A.M.A., Grajdeanu , I.V., Stefani , C., Bejan, C., Paparau, C., Diaconu, C. The role of vitamin D in the skin. Practica Medicala 2018;13,4(61): 251-254.
[12]
Norman, P.E., Powell, J.T. Vitamin D and cardiovascular disease. Circ Res. 2014;114(2): 379–393.
[13]
Manson, J.E., Bassuk , S.S., Lee , I.M., et al. The VITamin D and OmegA -3 TriaL (VITAL): Rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials. 2012;33: 159–171.
[14]
Zhang, R., Li, B., Gao, X., et al. Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies. Am J Clin Nutr. 2017;105: 810–819.
[15]
Chen, S., Law, C.S., Grigsby, C.L., et al. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011;124:1838–1847.
[16]
Socea, B., Nica, A.A., Smaranda, C.A., Carap, A.C., Socea, L.I., Dimitriu, M., Bratu, O.G., Moculescu, C.E., Bertesteanu, S.V.G., Constantin, V.D . Solitary cecum diverticulitis – a surprising diagnosis. Archives of the Balkan Medical Union. 2017;52(4): 467-470.
[17]
Radulescu, D., Balcangiu Stroescu, A., Pricop, C., Geavlete, B., Negrei, C., Bratu, O., Ginghina, O., Vacaroiu, I . Vitamin K influence on cardiovascular mortality in chronic hemodialysed patients. Rev Chim (Bucharest). 2017;68(1): 52-54.
[18]
Tica, O.A., Tica, O., Antal, L., Hatos, A., Popescu, M.I., Pantea Stoian, A., Bratu, O.G., Gaman, M.A., Pituru, S.M., Diaconu, C.C . Modern oral anticoagulant treatment in patients with atrial fibrillation and heart failure: insights from the clinical practice. Farmacia. 2018; 6 6(6): 972-976.
[19]
Raymond, M.A., Desormeaux, A., Labelle, A., et al. Endothelial stress induces the release of vitamin D-binding protein, a novel growth factor. Biochem Biophys Res Commun. 2005;338: 1374–1382
[20]
Martinesi, M., Bruni , S., Stio , M., Treves , C. 1,25-Dihydroxy-vitamin D3 inhibits tumor necrosis factor-alpha-induced adhesion molecule expression in endothelial cells. Cell Biol Int. 2006 ;30: 365– 375.
[21]
Weishaar, R.E., Kim , S.N., Saunders , D.E., Simpson , R.U. Involvement of vitamin D3 with cardiovascular f unction. III. Effects on physical and morphological properties. Am J Physiol. 1990;258: E134–E142.
[22]
Deng, G.G., Martin-McNulty, B., Sukovich, D.A., et al. Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm. Circ Res. 2003;92: 510–517.
[23]
Stanescu, A.M.A., Grajdeanu , I.V., Totan , A., et al. The complex context of the involvement of vitamin D deficiency in obesity. Rev Chim (Bucharest) 2019;70(10): 3654-3656.
[24]
Iancu, M.A., Bejan , C.G., Stanescu, A.M.A., et al . Deficitul de vitamina D in asistenta medicala primara. Revista Medicala Romana, 2018;LXV(1): 37-40.
[25]
Stanescu, A.M.A., Matei, A., Grajdeanu, I.V., et al. Sindromul metabolic in raport cu nivelul seric al vitaminei D corelat cu afectarea cutanată. Revista Medicala Romana. 2017;LXIV(4): 300-304.
[26]
Aleksova, A., Belfiore, R., Carriere, C., et al. Vitamin D deficiency in patients with acute myocardial infarction: an Italian single-center study. Int J Vitam Nutr Res. 2015; 85(1–2): 23–30.
[27]
De Metrio, M., Milazzo, V., Rubino, M., et al. Vitamin D plasma levels and in -hospital and 1 -year outcomes in acute coronary syndromes: a prospective study. Medicine (Baltimore) . 2015;94(19): e857.
[28]
Glueck, C.J., Jetty, V., Rothschild, M., et al. Associations between serum 25 -hydroxyvitamin D and lipids, lipoprotein cholesterols, and homocysteine. N Am J Med Sci. 2016;8(7): 284–90.
[29]
Gondim, F., Caribe , A., Vasconcelos, K.F., Seg undo, A.D., Bandeira , F. Vitamin D deficiency is associated with severity of acu te coronary syndrome in patients with type 2 diabetes and high rates of sun exposure. Clin Med Insights Endocrinol Diabetes. 2016; 9:37–41.
[30]
Zostautiene, I., Jorde , R., Schirmer, H., et al. Genetic variations in the vitamin D receptor predict type 2 diabete s and myocardial infarction in a community -based population: t he Tromso Study. PLoS One. 2015;10(12):e0145359.
[31]
Yao, T., Ying , X., Zhao , Y., et al. Vitamin D receptor activation protects against myocar dial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Antioxid Redox Signal. 2015;22(8):633–50.
[32]
Seker, T., Gur , M., Ucar , H., et al . Lower serum 25 -hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertens ive patients. Anatol J Cardiol. 2015;15(9):744–50.
[33]
Socea, B., Nica, A.A., Bratu, O., Diaconu, C., Smaranda, A., Socea, L., Bertesteanu, S., Dimitriu, M., Carap, A., Constantin, V. Incidental finding of a sigmoid intussusception associated with rectal prolapse – a case report. Arch Balk Med Union. 2018;53(1):143-146.
[34]
Ginghina, O., Negrei , C., Hudita , A., Ioana -Lavric, V., Galateanu , B., Dragomir , S., Burcea Dragomiroiu, G.T.A., Barca, M., Nitipir, C., Diaconu , C.C., Pantea Stoian , A.M., Iordache, N., Balanescu, A. In vitro impact of some natural compounds on HT -29 colorectal adenocarcinoma cells. Farmacia. 2017;65(6):947-953.
[35]
Manea, M., Marcu, D., Pantea Stoian , A., Gaman, M.A., Gaman, A.M., Socea, B., Neagu, T.P., Stanescu, A.M.A., Bratu , O.G., Diaconu , C.C. Heart failure with preserved ejection fraction and atrial fibrillation: a review. Rev Chim (Bucharest). 2018;69(11):4180 -4184.
[36]
Diaconu, C. Sindromul metabolic. Editura Medicala (Bucharest), 2011. ISBN 978-973-39-0713-8.
[37]
Diaconu, C., Nastasa, A., Zaki, A.R., Arsalan, M. Type 2 diabetes: a driver for chronic heart failure. The 2 nd International Conference on Interdisciplinary Management of Diabetes Mellitus and its Complications – Diabetes mellitus as cardiovascular disease. INTERDIAB 2016 Proceedings, pag. 201-210. Editura Niculescu. Editors Cristian Serafinceanu, Octavian Negoita, Viviana Elian.
[38]
Somaratne, J.B., Whalley, G.A., Poppe, K.K., Bals M.M., Wadams, G., Pearl, A., et al. Screening for left ventricular hypertrophy in patients with type 2 diabetes me llitus in the community. Cardiovasc Diabetol. 2011;10:29.
[39]
Fan, Y., Zhang, S.X., Ren, M., Hong, L.F., Yan, X.N. Impact of 1,25 -(OH)2D3 on left ventricular hypertrophy in type 2 diabetic rats. Chin Med Sci J. 2015;30(2):114–20.
[40]
Polat, V., Bozcali , E., Uygun , T., Opan , S., Karakaya , O. Low vitamin D status associated with dilated cardiomyopathy. Int J Clin Exp Med. 2015;8(1):1356–62.
[41]
Yilmaz, O., Kilic , O., Ciftel , M., Hakan , N. Rapid response to treatment of heart failure resulting from hypocalcemic cardiomyopathy. Pediatr Emerg Care. 2014;30(11):822–3.
[42]
Laranjo, S., Trigo , C., Pinto , F.F. Dual etiology of dilated cardiomyopathy: the synergistic role of vitamin D deficiency. Rev Port Cardiol. 2014;33(3):179e1–4.
[43]
Glenn, D.J., Cardema, M.C., Gardner, D.G. Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse. J Steroid Biochem Mol Biol. 2016; 164:292–8.
[44]
Cartier, J.L., K ukreja, S.C., Barengolts , E. Lower serum 25 -hydroxyvitamin D is associated with obesity but not common chronic conditions: an observational study of African American and Caucasian male veterans. Endocr Pract. 2017;23(3):271-278.
[45]
Seferovic, P.M., Paulus, W.J. Clinical diabetic cardiomyopathy: a two -faced disease with restrictive and dilated phenotypes. Eur Heart J. 2015;36(27):1718–27. 1727a–1727c.
[46]
Gullestad, L., Ueland , T., Vinge , L.E., Finsen , A., Yndestad , A., Aukrust , P. Inflammatory cytokines in heart failure: mediators and markers. Cardiology. 2012 ; 122(1):23–35.
[47]
Schleithoff, S.S., Zittermann, A., Tenderich, G., Berthold, H.K., Stehle, P., Koerfer, R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double -blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006; 83(4):754–9.
[48]
Manea, M., Marcu , D., Motofei , I., Socea , B., Pantea Stoian , A., Bratu , O.G., Gaman , M.A., Gaman, A.M., Stanescu, A.M.A., Mazur Nicorici, L., Diaconu, C.C. Cardiovascular risk in patients with inflammatory bowel diseases: a review. Romanian Biotechnological Letters. 2019;24(2):366-373.
[49]
Schierbeck, L.L., Jensen, T.S., Bang, U., Jensen, G., Kober, L., Jensen, J.E. Parathyroid hormone and vitamin D -markers for cardiovascular and all cause mortality in heart failure. Eur J Heart Fail. 2011;13(6):626–32.
[50]
Witte, K.K., Byrom, R., Gierula, J., Paton, M.F., Jamil, H.A., Lowry, J.E, et al. Effects of vitamin D on cardiac function in patients with c hronic HF: The VINDICATE Study. J Am Coll Cardiol. 2016;67(22):2593–603.
[51]
Schroten, N.F., Ruifrok, W.P., Kleijn, L., Dokter, M.M., Sillje, H.H, Lambers Heerspink, H.J., et al. Short-term vitamin D3 supplementation lowers plasma renin activity in patients with stable chronic heart failure: an open -label, blinded end point, randomized prospective trial (VitD -CHF trial) . Am Heart J. 2013;166(2):357–64. e2.
[52]
Belen, E., Aykan, A.C., Kalaycioglu, E., Sungur, M.A., Sungur, A., Cetin, M. Low-level vitamin D is associated with atrial fibrillation in patients with chronic heart f ailure. Adv Clin Exp Med. 2016;25(1):51–7.
[53]
Diaconu, C., Dumitru , N., Fruntelata , A,, Lacau, S., Bartos , D. Apical hypertrophic cardiomyopathy: the ace-of-spades as the disease card. Acta Cardiologica Sinica. 2015;31(1):1:83-86.
[54]
Stanescu, A.M.A., Grajdeanu, I.V., Iancu, M.A., Pantea Stoian, A., Bratu, O.G., Socea, B., Socea, L.I., Diaconu, C.C. Correlation of o ral vitamin D administration with the severity of psoriasis and the presence of metabolic syndrome. Rev Chim (Bucharest). 2018;69(7):1668 -1672.
[55]
Canpolat, U., Aytemir , K., Hazirolan, T., Ozer, N., Oto, A. Relationship between vitamin D level and left atrial fibrosis in patients with lone paroxysmal atrial fibrillation undergoing cryoballoon -based catheter ablation. J Cardiol. 2017;69(1):16–23.
[56]
Emren, S.V., Aldemir, M., Ada, F. Does deficiency of vitamin D increase new onset atrial fibrillation after coronary artery bypass grafting surgery? Heart Surg Forum. 2016; 19(4):E180–4.
[57]
Qu, H., Lin , K., Wang , H., Wei , H., Ji , B., Yang , Z., et al . 1,25(OH)2 D3 improves cardiac dysfunction, hypertrophy, and fibrosis through PARP1/SIRT1/mTOR-related mechanisms in type 1 diabetes. Mol Nutr Food Res. 2017;61(5). doi: 10.1002/mnfr.201600338
[58]
Tian, Y., Lv, G., Yang, Y., Zhang, Y., Yu, R., Zhu, J., et al. Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. Int J Clin Exp Pathol. 2014;7(6):3028–37.
[59]
Saxena, A., Chen , W., Su , Y., Rai , V., Uche , O.U., Li , N., et al . IL -1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J Immunol. 2013;191(9):4838–48
[60]
Fujii, H., Nakai, K., Yonekura, Y., Kono, K., Goto, S., Hirata, M., et al . The vitamin D receptor activator maxacalcitol provides cardioprotective effects in diabetes m ellitus. Cardiovasc Drugs Ther. 2015;29(6):499–507.