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Research Articles Supplement 1 · 2020 · pp. 67–74 · Issue page

IMMUNOGLOBULINS: FUNCTIONS, BIOSYNTHESIS AND BIOLOGICAL PROPERTIES

DA
Daniela BADEA1
AM
Amelia GENUNCHE-DUMITRESCU2
MI
Mihail BADEA3
CR
Cristian MARINAȘ4
TI
Tiberiu ȚENEA COJAN5
1 Clinical Hospital of Emergency Craiova, Department of Physiology, University of Medicine and Phar macy Craiova, Romania
2 Clinical Hospital of Emergency Craiova, 1st Medical Clinic, University of Medicine and Pharmacy Craiova, Romania
3 Clinical of Hematology, Filantropia Hospital of Craiova, Romania
4 Clinical Hospital of Emerg ency Craiova, Department of Ana tomy, University of Medicine and Pharmacy, Romania
5 CFR Hospital, Surgery Department, University of Medicine and Pharmacy Craiova, Romania
DOI https://doi.org/10.38173/RST.2020.S1.8:67-74
Received 15 March 2020
Revised -
Accepted 13 April 2020
Available Online 02 June 2020
Abstract
IMMUNOGLOBULINS SYNTHESIS IS THE DEFINING PROPERTY OF B LYMPHOCYTES A ND PLASMA CELLS. RESTING B LYMPHOCYTES SYNTHESIS ONLY SMALL AMOUNTS OF IMMUNOGLOBULINS THAT INSERTED INTO THE CELL MEMBRANE. PLASMA CELLS ARE SPECIALIZED TO PRODU CE AND SECRETE LARGE AMOUNTS OF IMMUNOGLOBULINS. ANTIBODY MOLECULES HAVE TWO MA JOR FUNCTIONS: ANTIGEN BINDING IS A FUNDAMENTAL FUNCTION WICH DEPENDS ON THE VARIABLE REGIONS LOCATED ON THE Fab REGION OF THE MOLECULE AND Fc REGION INTERESTED IN PLACENTAL TRANSFER, COMPLEMENT FIXATION AND BINDING TO Fc RECEPTORS. BIOLOGICAL PROCESSES (OPSONIZATION, M AST CELL DEGRANULATION, etc.) ARE POSSIBLE DUE TO THE PRESENCE OF RECEPTORS FOR Fc PORTION FOR VARIOUS TYPES ON GI ON CELLS THAT PARTICIPATE IN IMUNITY
Keywords
IMMUNOGLOBULINS COMPLEMENT Fc RECEPTORS.
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References
[1]
Abbas AK, Lichtman AH, Pillai S . Cellular and Molecular Immunology, Saunders, imprint of: Elsevier: Inc, eight edition, 2015.
[2]
Badea M, Badea D, Genunche-Dumitrescu A. Imuno-hematologie clinică. Ed. Sitech, 2013.
[3]
Catherine Sheehan. Immunoglobulin structure and function, In Clinical Immunology: principles and laboratory diagnosis 2nd ed; Lippincott-Raven, 1997.
[4]
Chapel H, Haeney M, Misbah S et al. Essentials of Clinical Immunology, 6 th Edition Wiley - Blackwell, 2014.
[5]
Delves PJ, Martin SJ, Burton DR et al. Roitts Essential Immunology. Ed. Wiley, Edition 13, 2017.
[6]
Gergely J, and Sarmay G . The two binding-site models of human IgG binding Fc  receptor. FASE J, 1998, 4:3275.
[7]
Hawley L, Ziegler RJ, Clarke BL. Microbiology and Immunology, Lippincot Williams &Wilkins, sixth ed, 2014.
[8]
Male D, Brostoff J, Roth DB et al. Immunology, 8th edition, Elsevier. Saunders, 2012.
[9]
Metzer H. Fc receptors and membrane immunoglobulins, Curr. Opin Immunol, 1999, 3:40.
[10]
Sompayrac L. How The Immune Sistem Works, Wiley-Blackwell, 5th edition, 2016.
[11]
Van Oss CJ and van Regenmortel MHV. Immunoglobulin structure and function, Immunochemistry, Marcel Dekker, New York, 1994.
[12]
Wienands J. The B-cell antigen receptor: formation of signaling complexes and the function of adaptor proteins. Current topics in microbiology and immunology, 2000, 245 (1), p 53 -76.