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Research Articles Supplement 2 · 2019 · pp. 172–181 · Issue page

HPV AND BUSCHKE-LOWENSTEIN DISEASE

DA
Dan Arsenie SPINU. Dan MISCHIANU1
DA
Dan MISCHIANU2
DR
Dragos Radu MARCU3
CA
Camelia C. DIACONU4
AN
Ana Maria Alexandra STANESCU5
CL
Claudia MEHEDINȚU6
BO
Bogdan SOCEA7
OV
Ovidiu Gabriel BRATU8
MA
Madalina CRIVEANU9
1 MD, Department of Urology, Emergency University Central Military Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, Bucharest
2 MD, Department of Urology, Emergency University Central Military Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, Bucharest; Academy of Romanian Scientists, Bucharest
3 MD, Department of Urology, Emergency University Central Military Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, Bucharest
4 MD, Department of Internal Medicine, Clinical Emergency Hospital of Bucharest, Bucharest; ”Carol Davila” University of Medicine and Pharmacy, Bucharest
5 MD, ”Carol Davila” University of Medicine and Pharmacy, Bucharest
6 MD, Department of Obstetrics and Gynecology, Clinical Hospital ”Nicolae Malaxa” Bucharest, Romania, ”Carol Davila” University of Medicine and Pharmacy Bucharest
7 MD, Department of Surgery, Saint Pantelimon Emergency Hospital, Bucharest; ”Carol Davila” University of Medicine and Pharmacy Bucharest
8 MD, Department of Urology, Emergency University Central Military Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, Bucharest; Academy of Romanian Scientists, Bucharest
9 MD, ”Carol Davila” University of Medicine and Pharmacy Bucharest
Accepted 29 March 2026
Available Online 20 July 2019
Abstract
INTRODUCTION. HUMAN PAPILLOMAVIRUS (HPV) IS A VIRAL INFECTION WHICH GENERATES EPITHELIAL TUMOURS OF THE MUCOUS MEMBRANES AND SKIN ESPECIALLY WARTS. THE DIMENSIONS OF THE WARTS COULD VARY AMONG INDIVIDUALS FROM A FEW MILLIMETRES TO A CONSIDERABLE SIZE BEING CALLED GIANT CONDYLOMA ACUMINATUM (GCA). THIS GIANT CONDYLOMA ACUMINATUM WAS FIRST DESCRIBED BY BUSCHKE AND LÖWENSTEIN IN 1925 ON PENILE FORESKIN, NOWADAYS KNOWN AS BUSCHKE – LOWENSTEIN TUMOUR (BLT). MATERIAL AND METHODS. THE PURPOSE OF THIS PAPER IS TO REVIEW THE AVAILABLE DATA REGARDING THE ETIOPATHOGENY OF BLT DIAGNOSIS AND NEW LINES OF TREATMENT. WE USED PUBMED AND SCOPUS DATABASES FOR REVIEWS AND FULL ARTICLES. CONCLUSIONS. BUSCHKE – LOWENSTEIN IS A RARE DISEASE CAUSED BY INFECTION WITH HPV, ESPECIALLY ASSOCIATED WITH ”SEMI – MALIGNANT ” VERRUCOUS CARCINOMA OR SQUAMOUS CELL CARCINOMA. COINFECTION WITH HIV ENHANCE THE ONCOGENIC ABILITY OF HPV, BUT THE ONCOGENIC PROCESS IS SLOW, SO AN EARLY REMOVAL OF THE LESION WHEN NOTICED BY THE PATIENT IS USEFUL TO PREVENT A GCA. PRE-EXPOSURE AND POST-EXPOSURE VACCINES ARE VERY IMPORTANT IN PREVENTING BLT AND REDUCING THE VIRAL LOAD IN THE INFECTED.
Keywords
HPV BUSCHKE-LOWENSTEIN RARE DISEASE
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