THE PERI-APPENDICEAL RED PATCH: A TRADEMARK SKIP LESION IN ULCERATIVE COLITIS

CONVENTIONALLY, UC IS RECOGNIZED AS A DISEASE WITH CONTINUOUS MUCOSAL INFLAMMATION THAT EXTENDS FROM THE RECTUM TO THE PROXIMAL PART OF THE COLON, BUT DURING THE LAST DECADE, A PARTICULAR PATTERN OF COLITIS THAT INVOLVES THE DISTAL COLON WITH A NORMAL APP EARANCE MUCOSA INTERPOSED AND A WELL DEFINED AREA OF INFLAMMATION AROUND THE APPENDI X HAS BEEN HIGHLIGHTED. WE USED A TERTIARY CARE CENTER EVIDENCES TO ANALYZE THE CHARACTERISTICS OF UC PATIENTS WITH PARP. WE EVALUATED 76 PATIENTS WHO WENT TO OUR CLINIC FOR INVESTIGATING CHRONIC DIARRHEA SYNDROME BETWEEN JANUARY 2018 -DECEMBER 2020 AND F OR WHOM A DIAGNOSIS OF ULCERATIVE COLITIS WAS ESTABLISHED . ONLY 7 PATIENTS HAD ENDOSCOPICALLY ASPECT OF PARP (THIS HAPPENED DURING FOLLOW -UP ENDOSCOPY), ASPECT SUPPORTED A LSO BY THE HISTOLOGICAL DESCRIPTION (NANCY INDEX SCORE). DURING FOLLOW-UP, MOST PATIENTS WITH PARP KEPT THE SAME EXTENT OF LESIONS. CONCLUSIONS: WE CONFIRM THE PRESENCE OF PARP AS A “SKIP LESION” IN DISTAL UC, DIAGNOSTIC SUPPORTED ALSO BY THE HISTOPATHOLOG IST, AND EVEN THOUGH WE ARE CONFIDENT IN THE DIAGNOSIS OF ULCERATIVE COLITIS, ONE P ATIENT HAD A CROHN'S DISEASE PHENOTYPE SWITCH DURING THE EVOLUTION. NONETHELESS, WE CANNOT CONCLUDE THAT PARP HAS A ROLE IN THE EXTENSION OF LESIONS, REMISSION OR RELAPSE OF DISEASE, GIVEN THE FACT THAT WE DO NOT HAVE A SUFFICIENT GROUP OF ELIGIBLE PATIENT S, FOR WHICH REASON DETAILED STUDIES ARE NEEDED.

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