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Research Articles Issue 1 · 2017 · pp. 161–171 · Issue page

SOCIAL DETERMINANTS AND OXIDATIVE STRESS AMONG ELDERLY PATIENTS WITH CARDIOVASCULAR DISEASES – TWO FACETS OF THE SAME MATTER

AN
Andreea SERBAN1
MI
Minodora IORDACHE2
AN
Andreea HODOROGEA3
CR
Cristian TOMA4
SE
Sean MAHER5
AD
Adriana ILIESIU6
IO
Ioan Tiberiu NANEA7
1 MD, PhD Attending, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
2 MD, Department of Biophysics and Cell Biotechnology, University of Medicine and Pharmacy “Carol Davila”
3 MD, Cardiology Department, Hospital "Prof. Th. Burghele "
4 MD, Cardiology Department, Hospital "Prof. Th. Burghele "
5 MD, Cardiology Department, Hospital "Prof. Th. Burghele "
6 MD, Cardiology Department, Hospital "Prof. Th. Burghele "
7 MD, Cardiology Department, Hospital "Prof. Th. Burghele "
Corresponding author: [email protected]
Accepted 28 March 2026
Available Online 15 March 2017
Abstract
CARDIOVASCULAR DISEASE (CVD) IS THE NUMBER ONE CAUSE OF DEATH WORLDWIDE.[1] AND ITS PREVALENCE IS PREDICTED TO RISE EXPENDENTIALLY IN THE COMING YEARS. THERE IS A COMPLEX INTERPLAY BETWEEN THE UNDERLYING HEALTH DETERMINANTS THAT COULD TRIGGER ANY PATHOPHYSIOLOGICAL ABNORMALITY LEADING TO THE DEVELOPMENT OF DISEASE[4]. THIS ARTICLE FOCUSES ON THE TWO WAY TICKET THAT IS OXIDATIVE STRESS (OS) AND SOCIAL DETERMINANTS IN THE DEVELOPMENT OF CVD. IT IS BECOMING INCREASINGLY CLEAR THAT SOCIOECONOMIC FACTORS PLAY A MAJOR ROLE IN THE DEVELOPMENT OF CVD. IN ADDITION, A MULTITUDE OF RESEARCH PAPERS HAVE SHOWN DISADVANTAGEOUS SOCIAL FACTORS CAN TRIGGER AN INCREASE IN ROS PRODUCTION. OUR KNOWLEDGE OF hROS HAS EVOLVED IN THE PAST DECADES TO THE POINT THAT WE NOW HAVE WELL DOCUMENTED EVIDENCE SUPPORTING THE ROLE OF hROS (E.G. PEROXYNITRITE, HYPOCHLORIT E, HYDROXYL RADICAL) IN THE MECHANISM OF ENDOTHELIAL DYSFUNCTION, VASCULAR COMPLICATIONS, MYOCARDIAL INFARCTION, CONGESTIVE HEART FAILURE AND STROKE[4]. ON THE OTHER HAND, SOCIAL DETERMINANTS ARE YET ANOTHER FACET OF THE SAME MATTER. RECENT DATA EMPHASISES THE CAPACITY OF SOCIAL DETERMINANTS AND SOCIAL CONFIGURATION TO DETERMINE THE DEVELOPMENT OF CVD[3]. MOREOVER, THE DYNAMIC NATURE OF HOW THE SOCIAL ENVIRONMENT ACTS UPON DISEASE NECESSITATES AN INDEPTH INVESTIGATION. AS A CONSEQEUNCE, IN ORDER TO PROPERLY ADDRESS THE INCREASE IN CVD, BOTH PATHOPHYSIOLOGICAL AND SOCIAL ASPECTS SHOULD BE TAKEN EQUALLY INTO CONSIDERATION.
Keywords
CARDIOVASCULAR DISEASE AGING SOCIAL DETERMINANTS REACTIVE OXYGEN SPECIES
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