LOCAL FOREIGN BODY RESPONSE TO ORTHOPAEDIC BIOMATERIAL IMPLANTS

THE SURGICAL MANAGEMENT OF BONE LESIONS OFTEN INVOLVES IMPLANTATION OF SURGICAL DEVICES SUCH AS JOINT PROSTHESIS, PLATES, NAILS AND / OR SCREWS IN ORDER TO TREAT DEGENERATIVE PATHOLOGIES OR POSTTRAUMATIC LESIONS. IN MOST CASES THE SURGICAL TREATMENT IS A SUCCESS WHEN BONE HEALING OR PAIN MANAGEMENT IS ACHIEVED, BUT IN SOME CASES THE INFLA MMATORY RESPONSE SECONDARY TO BIOMATERIALS IMPLANTATION CAN LEAD TO CHRONIC PAIN, FUNCTIONAL IMPAIRMENT AND LOCAL INFECTION. THESE LOCAL COMPLICATIONS CAN HAVE IMPORTANT SIDE EFFECTS, SOMETIMES THE ONLY REMEDY BEING THE EXTRACTION OF THE BIOMATERIAL. OF COURSE, IF BONE HEALING IS ACHIEVED THE EXTRACTION OF THE BIOMATERIAL IS NOT A BIG PROBLEM BUT, IN SOME CASES, THE LOCAL INFLAMMATORY RESPONSE AND CLINICAL MANIFESTATIONS CAN REQUIRE EARLY SURGICAL MANAGEME NT WITH THE EXTRACTION OF THE DEVICE; IN THESE CAS ES, SURGICAL MANAGEMENT WITH FURTHER OSTEOSYNTHESIS TECHNIQUES IS NECESSARY, WITH A GREAT IMPACT IN THE SOCIAL REINTEGRATION OF THE PATIENT BY PROLONGED INFIRMITY. IN THE PRESENT STUDY WE TRIED TO FIND THE MAIN CHARACTERISTICS THAN CAN LEAD TO INCREASED LOCAL INFLAMMATORY RESPONSE TO BIOMATERIALS IN ORDER TO LIMIT THE NEED FOR SURGICAL REINTERVENTIONS..

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