Submit Manuscript Now
Current issue Archive Authors Profile
Research Articles Supplement 3 · 2014 · pp. 79–86 · Issue page

PREVALENCE OF CELIAC DISEASE IN WOMEN WITH FERTILITY DISORDERS

CO
Cosmin CIORA1
AL
Alexandru LUPU2
MI
Mircea DICULESCU3
1 Gastroenterology and Hepatology Clinic, Fundeni Clinical Institute; UMF Carol Davila, Gastroenterology and Hepatology Fundeni
2 Gastroenterology and Hepatology Clinic, Fundeni Clinical Institute; UMF Carol Davila, Gastroenterology and Hepatology Fundeni
3 Gastroenterology and Hepatology Clinic, Fundeni Clinical Institute; UMF Carol Davila, Gastroenterology and Hepatology Fundeni
Corresponding author: [email protected]
Accepted 27 March 2026
Available Online 15 December 2014
Abstract
BECAUSE SUBCLINICAL CE LIAC DISEASE MAY DECREASE FERTILITY OR COMPLICATE PREGNANCY, WE SCREENED WOMEN WITH FERTILITY DISORDERS AND WOMEN WITH FUNCTIONAL DYSPEPSIA, FOR ANTI-TISSUE TRANSGLUTAMINASE ANTIBODIES IN SERUM TO FIND UNDIAGNOSED CELIAC DISEASE. METHOD: WE SCREENED WOMEN WITH RECURRENT MISCARRIAGE OF UNKNOWN AETIOLOGY (N = 36), UNEXPLAINED INFERTILITY (N = 46) AND WOMEN WITH FUNCTIONAL DYSPEPSIA (N = 112), FOR ANTI-TISSUE TRANSGLUTAMINASE ANTIBODIES IN SERUM TO FIND UNDIAGNOSED CELIAC DISEASE. ONE WOMAN (2.7%) WITH RECURRENT MISCARRIAGE, TWO WOMEN (4.35%) WITH UNEXPLAINED INFERTILITY AND ONE WOMAN IN THE CONTROL GROUP (0.9%), WERE CONSIDERED TO HAVE CELIAC DISEASE. ALL WOMEN WITH POSITIVE SEROLOGIC FINDINGS (4 CASES) UNDERWENT JEJUNAL BIOPSY AND OF THEM HAD HISTOLOGICAL EVIDENCE OF CELIAC DISEASE. RESULTS: THE PREVALENCE OF CELIAC DISEASE IN INFERTILE WOMEN SEEMS HIGHER (3 OUT OF 82, 3.65%) IN THE STUDY GROUP THAN IN THE GENERAL POPULATION (1 OUT OF 112, 0.9%), AND PARTICULARLY IN THE SUBGROUP WITH UNEXPLAINED INFERTILITY (2 OUT OF 46, 4.35%) CONCLUSIONS: UNDIAGNOSED CELIAC DISEASE IS A RISK FACTOR FOR INFERTILITY AND RECURRENT MISCARRIAGE OF UNKNOWN AETIOLOGY. WOMEN SEEKING MEDICAL ADVICE FOR THIS PARTICULAR CONDITION SHOULD BE SCREENED FOR CELIAC DISEASE. ADOPTION OF A GLUTEN-FREE DIET COULD HAVE A POSITIVE IMPACT ON FERTILITY IN THIS GROUP OF PATIENTS. IT SEEMS RATIONAL THAT SEROLOGICAL TESTS SHOULD BE PERFORMED AS ROUTINE INVESTIGATION IN THESE CASES. THE RECOMMENDED STRATEGY IS INDIVIDUALLY CASE-ORIENTED.
Keywords
CELIAC DISEASE INFERTILITY ANTI-TISSUE TRANSGLUTAMINASE
Full Text
The body of this article is intentionally hidden on the public page. Please use the PDF reader or the PDF download for the complete text.
References
[1]
Celiac Disease.Peter H.R. Green, M.D., and Christophe Cellier, M.D ., Ph.D.N Engl J Med 2007; 357:1731-1743 October 25, 2007DOI: 10.1056/NEJMra071600
[2]
Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy. Petrarca L , Nenna R , Mastrogiorgio G, Florio M, Brighi M, Pontone S. World J Methodol. 2014 Sep 26;4(3):189 -96. doi: 10.5662/wjm.v4.i3.189. ECollection 2014.
[3]
Tiboni GM, Grazia de Vita M, Faricelli R, et al. Serological testing for celiac disease in women undergoing assisted reproduction techniques. Hum Reprod. 2006;21(2):376–379
[4]
Gasbarrini A, Torre ES, Trivellini C , et al. Recurrent spontaneous abortion and intrauterine fetal growth retardation as symptoms of celiac disease. Lancet. 2000;356(9227):399–400.
[5]
Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy. Petrarca L , Nenna R , Mastrogiorgio G, Florio M, Brighi M, Pontone S. World J Methodol. 2014 Sep 26;4(3):189 -96. doi: 10.5662/wjm.v4.i3.189. eCollection 2014.
[6]
Meloni GF, Dessole S, Vargiu N, et al. The prevalence of celiac disease in infertility. Hum Reprod. 1999;14(11):2759–2761
[7]
Reproductive life disorders in Italian celiac women. A case -control study. Domenico Martinelli , Francesca Fortunato, Silvio Tafuri, Cinzia A Germinario, BMC Gastroenterol 2010; 10:89.
[8]
Review [Reproductive aspects of celiac disease]. Stazi AV, Trinti B. Ann Ital Med Int. 2005 Jul -Sep; 20(3):143-57.
[9]
All Roads Lead to Rome: Update o n Rome III Criteria and New Treatment Options. Shih DQ1, Kwan LY. Gastroenterol Rep. 2007 Winter;1(2):56-65.
[10]
Stephen EH, Chandra A . Declining estimates of infertility in the United States: 1982 –2002. Fertil.Steril 2006;86(3):516–523. [PubMed: 16952500
[11]
Clinical Utility of Serologic Testing for Celiac Disease in Asymptomatic Patients.An Evidence -Based Analysis.Ont Health Technol Assess Ser. 2011; 11(3): 1–63.
[12]
Reproductive changes associated with celiac disease. Hugh James Freeman . World J Gastroenterol. Dec 14, 2010; 16(46): 5810–5814.
[13]
Clinical Utility of Serologic Testing for Celiac Disease in Asymptomatic Patients.An Evidence -Based Analysis.Ont Health Technol Assess Ser. 2011; 11(3): 1–63.
[14]
Ford AC , Ching E, Moayyedi P . Meta -analysis: yield of diagnostic tests for coeliac disease in dyspepsia. Aliment Pharmacol Ther 2009; 30: 28 -36 [PMID: 19416130 DOI: 10.1111/j.1365 - 2036.2009.04008.x]
[15]
Celiac disease,anemia and pregnancy.Haslam N, Lock RJ, Unsworth DJ. Clin Lab 2001;47:467–9.
[16]
Halfdanarson TR, Litzow MR, Murray JA . Hematologic manifestations of celiac disease. Blood 2007; 109:412–21.
[17]
Bottaro G, Cataldo F, Rotolo N, Spina M, Corazza GR . The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol 1999;94:691–6.
[18]
Cosmin CIORA , Mircea DICULESCU . Fertility disorders associated to coeliac disease - retrospective study. Research and Science Today 2(8)/2014 , 231-238.