SERUM LEVELS OF ADIPONECTINE AND LEPTIN IN GESTATIONAL DIABETES MELLITUS - REVIEW
Received
12 December 2021
Revised
4 February 2022
Accepted
26 February 2022
Available Online
15 March 2022
Abstract
GESTATIONAL DIABETES MELLITUS (GDM) IS A METABOLIC COMPLICATION OF PREGNANCY. DUE TO THE EPIDEMY OF OVERWEIGHT AND OBESITY IN WOMEN AT REPRODUCTIVE AGE, PREVALENCE OF GDM IS INCREASING WORLDWIDE. GESTATIONAL DIABETES MELLITUS IS A PATHOLOGICAL STATUS CHARACTERIZ ED BY GLUCOSE INTOLERANCE W HICH IS ONSET OR FIRST RECOGNIZE IN PREGNANCY AND IS ASSOCIATED WITH SHORT AND LONG THERM MATERNO -FETAL COMPLICATIONS. UNDERSTANDING THE PHYSIOPATHOLOGY OF GDM IS AN IMPORTANT PROGRESS IN MANAGEMENT OF THESE CASES. BOTH MOTHER AN D CHILD PRESENT A HIGH RISK OF DEVELOPING TYPE 2 DIABETES MELLITUS (T2DM), OBESITY AND METABOLIC SYNDROME LATER IN LIFE. GDM COVERS LATENT METABOLIC CHANGES THAT GENERATE A TRANSGENERATIONAL VICIOUS CIRCLE. INSULIN RESISTANCE AND β-CELL DYSFUNCTION ARE INVOLVED IN P ATHOGENESIS OF GDM. OBESITY IS A RISK FACTOR OF DEVELOPING GDM. ADIPOSE TISSUE SECRETES ADIPOKINES INVOLVED IN PATHOPHYSIOLOGY OF GDM AND ALSO IN ENERGY HOMEOSTASIS, CARBOHYDRATE AND LIPID METABOLISM. THE PURPOSE OF THIS REVIEW WAS TO ANALYSIS SE RUM AD IPOCYTOKINES LEVELS IN PREGNANCIES COMPLICATED WITH GESTATIONAL DIABETES.
Keywords
GESTATIONAL DIABETES
PATHOGENESIS
ADIPOKINES
INSULIN RESISTANCE
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