NEUROENDOCRINE CELLS ALTERATIONS IN COLONIC MUCOSA OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE
Accepted
29 March 2026
Available Online
15 March 2019
Abstract
BACKGROUND AND AIMS: SEVERAL PUBLISHED STUDIES ON HUMAN AND ANIMAL MODELS
SHOWED INCREASED DENSITIES OF NEUROENDOCRINE CELLS (NE)CELLS IN COLONIC MUCOSA OF
INFLAMMATORY BOWEL DISEASE ( IBD) COLITIS. THE AIM OF OUR STUDY IS TO DETERMINE THE
(NE) CELLS DENSITIES IN COLONIC MUCOSA OF PATIENTS WITH (IBD).
METHODS: COLONIC BIOPSIES FROM 18 PATIENTS WITH IBD ( 8 ULCERATIVE COLITIS, 10 CHRON’S
DISEASE) AND 16 HEALTHY CONTROLS WERE EVALUATED HISTOPATOLOGIC WITH HEMATOXYLIN-
EOSIN AND IMMUNOHISTOCHEMICAL WITH CHROMOGRANIN A (CGA) AND SYNAPTOHYSIN(SYN)
ANTIBODIES.
RESULTS: NE CELLS WERE COUNTED ON A TOTAL MEDIAN NUMBER OF 24.1(7,56) CRYPTS FOR CGA,
24(5,57) FOR SYN IN IBD GROUP AND 29 (11,64) CRYPTS FOR CGA AND 29,2(11.52) CRYPTS FOR SYN
IN CONTROLS. THE TOTAL DENSITIES/SUBJECT OF NE CELLS WERE SIGNIFICANTLY HIGHER IN IBD GROUP COMPARED TO CONTROLS FOR BOTH CGA AND SYN: 1.45(0.72,2.78) AND 0.86(0.43,1.73) FOR CGA (P= 0,006), 0.89(0.22,1.63) AND 0.63(0.28,1.28) FOR SYN (P=0,025).
CONCLUSIONS: OUR STUDY SHOWED AN INCREASED DENSITY OF CGA AND SYN POSITIVE NEC IN
PATIENTS WITH IBD.
Keywords
ENDOCRINE CELLS
INFLAMMATORY BOWEL DISEASE
CHROMOGRANIN A
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