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Research Articles Issue 1 · 2021 · pp. 79–89 · Issue page

THE ROLE OF ZINC IN CHRONIC LIVER DISEASE

DA
Daniel-Cristian PÎRVU1
AL
Alina MIȘCOCI2
AD
Adriana-Estefa MUÑOZ-GROZA3
VL
Vlad Dumitru BĂLEANU4
IO
Ion SCURTU5
VE
Veronica GHEORMAN6
VI
Victor GHEORMAN7
1 Department of Inter nal Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania, .
2 Department of Internal Medicine, 4 th Department – Medical Specialti es 1, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
3 Oncology Departmen t, Filantropia Clinical Hospital, 1 Filantropia Street, 200134 Craiova, Romania
4 General Surgery Department, "Sf. Pantelimon" Emergency Clinical Hospital, 340 Sos. Pantelimon, 021659 Bucharest, Romania
5 Emergency University Hospital Bucharest, Surgery Department, Bucharest, Rom ania, 169 Independe ntei Street, 050098
6 Cardiology Department , Emergency County Clinical Ho spital of Craiova, 1 Tabaci Street, 200642 Craiova, Romania
7 Psychiatry Department , University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
Corresponding author: [email protected]
DOI https://doi.org/10.38173/RST.2021.21.1.7:79-89
Received 18 December 2020
Revised 13 February 2021
Accepted 03 March 2021
Available Online 15 March 2021
Abstract
ONE OF THE FUNDAMENTAL MICRONUTRIENTS N ECESSARY IN THE MECHANISM OF CELLULAR METABOLISM, PRODUCTION AND DIFFERENTIATION ARE ZINC. DUE TO ITS FINGER TRANSCRIPTION FACTORS, IT ALSO PLAYS AN IMPORTANT ROLE IN DNA SYNTHESIS, RNA PACKAGING AND CELL RENEWAL. THIS SPECIFIC TRACE ELEMENT IS METABOLIZED IN THE LIVER, SO ANY DISORDER THAT OCCURS AT THIS LEVEL CAN MODIFY THE ASSIMILATION OF ZINC . ALSO, AN INSUFFICIENT LEVEL OF ZINC CAN LEAD TO CHRONIC LIVER DISEASE. LIVER CIRRHOSIS REPRESENTS THE FINAL PATHOLOGICAL PA THWAY IN THE DEVELOPMENT OF MANY CHRONI C LIVER DISEASES REGARDLESS OF ETIOLOGY, THEREFORE ZINC MAY PLAY A ROLE IN ITS PROGRESSION AND OUTCOME . THIS REVIEW WILL ANALYZE THE LATEST FINDINGS ON THE IMPORTANCE OF ZINC IN CHRONIC LIVER DISEASE GENESIS AND PROGRESSION.
Keywords
ZINC CHRONIC LIVER DISEASE LIVER CIRRHOSIS.
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