BIOGENESIS OF EXOSOMES - A REVIEW OF CURRENT LITERATURE
Received
07 March 2020
Revised
4 April 2020
Accepted
18 April 2020
Available Online
02 June 2020
Abstract
EXOSOMES WERE FIRST REPORTED A FEW DECADES AGO AND THEY HAVE BEEN THE CENTER OF INTEREST OF RESEARCHERS DUE TO THEIR VARIOUS FUNCTIONS , THEIR CAPACITY TO MEDIATE INTERCELLULAR COMMUNICATION AND TO PROVIDE INFORMATION ABOUT THE ORIGIN CELL. EXOSOMES ARE EXTRACELLULAR VESICLES DERIVED FROM THE CELL MEMB RANE AND CONTAIN A WIDE VARIETY OF MOLECULES SUCH AS PROTEINS, RNAS, LIPIDS, AND FRAGMENTS OF GENOMIC DNA. STUDIES REPORT THAT DIFFERENT EXOSOME - DERIVED PROTEINS CAN SERVE AS BIOMARKERS FOR THE ISOLATION AND QUANTIFICATION OF EXOSOMES . ALL CELL TYPES SECRETE EXOSO MES AND DATA SUGGESTS THAT EXOSOMES RELEASED FROM METABOLICALLY ACTIVE CELLS CAN REPROGRAM THE TARGET CELL.
Keywords
EXOSOMES
CELL
PROTEINS
INFORMATION
BIOMARKERS
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References
[1]
Sahu R, Kausik S, Microautophagy of citosolic proteins by late endosomes. Dev Cell 2011, 131-9
[2]
G van Niel, G D’ Angelo, Sheddind light on the cell biology of extracellular vesicles. Nat Rev. Mol Cell Biol, 2018, 213-28
[3]
K. M. Mc Andrews, R Kalluri , Mechansims associated with biogenesis of exosomes in cancer. Mol. Cancer 18, 2019
[4]
Frängsmyr, L., Baranov, V., Nagaeva, O., Stendahl, U., Kjellberg, L., & Mincheva -Nilsson, L. (2005). Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular leve l. MHR: Basic Science of Reproductive Medicine, 11(1), 35–41.
[5]
Nina Pettersen Hessvik, Alicia Llorente, Current knowledg e on exosome biogenesis and release, July 2017, Cellular and Molecular Life Sciences CMLS 75(3)
[6]
L. Blanc, M,. Vidal, New insights into the function of Rab Gtp -ases in the context of exosomal secretion, Small GTPases, 2018
[7]
Sarker S, Scholz -Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C . Placenta - derived exosomes continuously increase in maternal circulation over the first trimester of preg nancy.J Transl Med. 2014;12:204.
[8]
Gregory E. Rice, Katherin Scholz -Romero, The Effect of Glucose on the Release and Bioactivity of Exosomes From First Trimester Trophoblast Cells JCEM, 2015
[9]
Savina, A., Furl án, M., Vidal, M., & Colombo, M. I. (2003 ). Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells. Journal of Biological Chemistry, 278(22), 20083 – 20090.
[10]
Dai, X. Q., Plummer, G., Casimir, M., Kang, Y., Hajmrle, C., Gaisano, H. Y., et al. (2011). SUMOylation regulates insulin exocytos is downstream of secretory granule docking in rodents and humans. Diabetes 60
[11]
MacDonald, P. E., Eliasson, L., and Rorsman, P . (2005). Calcium increases endocytotic vesicle size and accelerates m embrane fission in insulin -secreting INS-1 cells. J. Cell Sci. 118(Pt 24), 5911 –5920. doi: 10.1242/jcs.02685
[12]
Mathivanan S, Fahner CJ, Reid GE, Simpson RJ. ExoCarta 2012: database of exosomal proteins, RNA and lipids. Nucleic Acids Res. 2012;40(Database issue):D1241–D1244. doi: 10.1093/nar/gkr828.
[13]
Kim DK, Kang B, Kim OY, Choi DS, Lee J, Kim SR, Go G, Yoon YJ, Kim JH, Jang SC, Park KS, Choi EJ, Kim KP, Desiderio DM, Kim YK, Lotvall J, Hwang D, Gho YS. EVpedia: an integrated database of high -throughput data for systemic analyses of extracellular vesicles. J Extracell Vesicles. 2013
[14]
Carlos Salomon1 *, Miharu Kobayashi1 , Keith Ashman1 , Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes. Plos One 2013
[15]
Maxfield FR 1, Yamashiro DJ . Endosome acidification and the pathways of receptor -mediated endocytosis. Adv Exp Med Biol. 1987;225:189-98.