GALLBLADDER CARCINOMA -A SURPRISINGLY DIAGNOSIS
Accepted
28 March 2026
Available Online
15 September 2018
Abstract
GALLBLADDER CARCINOMA IS FAR TO BE AN EXTREMELY RARE DIAGNOSTIC. IT REPRESENTS THE FIFTH LOCATION IN FREQUENCY ORDER FOR DIGESTIVE TRACT MALIGNANCY. IT IS MORE FREQUENT THAN CHOLANGIOCARCINOMA. WE NOTICED RECENTLY (LAST YEARS) AN INCREASING NUMBER OF GALLBLADDER CARCINOMAS IN OUR CLINIC. MOST OF THEM ARE NOT DIAGNOSED PRE -OPERATIVELY. SOME CASES ARE INTRA - OPERATIVE SURPRISES AND SOM E ARE EVEN POST -OPERATIVE SURPRISES FROM HISTOPATHOLOGY LAB. THE ONCOLOGIC CORRECT SURGICAL TREATMENT ASSUMES A PRE -OPERATIVE DIAGNOSTIC, WHICH, UNFORTUNATELY, IS VERY RARE. SOME SPECIFIC CASES WITH AN ULTRASOUND RESULT SUGGESTING A TUMOR OF THE GALLBLADD ER UNDERGO AN ABDOMINAL CT SCAN OR MRI THAT COULD CONFIRM THE DIAGNOSIS. THE MOST COMMON MISMATCH IS ACUTE CHOLECISTITIS. IN THE LAST FIVE YEARS (2014 -2018), WE TREATED IN OUR SURGICAL CLINIC 11 CASES OF GALLBLADDER CARCINOMA.
Keywords
GALLBLADDER CANCER
SURPRISINGLY HISTOPATHOLOGICAL FINDING
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References
[1]
Strom BL, Soloway RD, Rios -Dalenz JL, et al . Risk factors for gallbla dder cancer: an international collaborative case-control study. Cancer 1995; 76:1747–1756.
[2]
Reid KM, Ramos -De la Medina A, Donohue JH. Diagnosis and surgical management of gallbladder cancer: a review. J Gastrointest Surg 2007; 11:671–681.
[3]
Rodríguez-Fernádez A, Gómez-Río M, Medina-Benitez A, et al. Application of modern imaging methods in diagnosis of gallbladder cancer. J Surg Oncol 2006; 93:650–664.
[4]
Matsusaka S, Yamasaki H, Kitayama Y, et al. Occult gallbladder carcinoma diagnosed by a laparoscopic cholecystectomy. Surg Today 2003; 33:740–742.
[5]
Shaffer EA. Gallbladder cancer: the basics. Gastroenterol Hepatol (N Y) 2008;4:737–741.
[6]
Draghici T, Negreanu L, Bratu O, Tincu R, Socea B, Iancu M, Stanescu AM, Diaconu C. Liver abnormalities in patients with heart failure. Arch Balk Med Union, 2018, 53(1): 76-81.
[7]
Paraschiv B, Dediu G, Iancu A, Bratu O, Diaconu C. Superior vena cava syndrome. Arch Balk Med Union, 2017, 52(1): 39-43.
[8]
Diaconescu D, Stoian Pantea A, Socea L, Stanescu AM, Iancu M, Socea B, Pituru S, Bratu O, Diaconu C. Hepatorenal Syndrome: A Review. Arch Balk Med Union, 2018, 53(2): 239-245.
[9]
Franquet T, Montes M, Ruiz de Azua Y, Jimenez FJ, Cozcolluela R. Primary gallbladder carcinoma: imaging findings in 50 patients with pathologic correlation. Gastrointest Radiol 1991; 16:143–148.
[10]
Corvera CU, Blumgart LH, Akhurst T, et al. 18Ffluorodeoxyglucose positron emission tomography influences management decision in patients with biliary cancer. J Am Coll Surg 2008; 206:57–65.
[11]
Soria Aledo V, Galindo Iñíguez L, Flores Funes D, Carrasco Prats M, Aguayo Albasini JL. Is cholecystectomy the treatment of choice for acute acalculous cholecystitis? A systematic review of the literature. Rev Esp Enferm Dig. 2017 Oct;109(10):708-718. doi: 10.17235/reed.2017.4902/2017.
[12]
Gu MG, Kim TN, Song J, Nam YJ, Lee JY, Park JS. Risk factors and therapeutic outcomes of acute acalculous cholecystitis. Digestion. 2014;90(2):75-80. doi: 10.1159/000362444.
[13]
Socea, Bogdan, Carâp, Alexandru C., Socea, Laura I., Dimitriu, Mihai, Bratu, Ovi diu G., Diaconu, Camelia C., Dumitrescu, Dan, Constantin, Vlad D. Acute ischemic cholecystitis in Takayasu’s syndrome – a rare finding. Arch Balk Med Union, 2018, 53(2): 293-6.
[14]
Castelijn DAR, Wattel-Louis GH. An acute acalculous cholecystitis in a returned travel couple. PLoS Negl Trop Dis. 2018;12(3):e0006177. Published 2018 Mar 8. doi:10.1371/journal.pntd.0006177.
[15]
Hemminki K, Li X. Familial liver and gall bladder cancer: a nationwide epidemiological study from Sweden. Gut. 2003;52:592–596.
[16]
Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clin Epidemiol. 2014;6:99–109.
[17]
Albores-Saavedra J, Alcántra-Vazquez A, Cruz-Ortiz H, Herrera-Goepfert R. The precursor lesions of invasive gallbladder carcinoma. Hyperplasia, atypical hyperplasia and carcinoma in situ. Cancer. 1980;45:919–927.
[18]
Roa I, Araya JC, Villaseca M, De Aretxabala X, Riedemann P, Endoh K, Roa J. Preneoplastic lesions and gallbladder cancer: an estimate of the period required for progression. Gastroenterology. 1996;111:232–236.
[19]
Vaittinen E. Carcinoma of the gall-bladder. A study of 390 cases diagnosed in Finland 1953-1967. Ann Chir Gynaecol Fenn Suppl. 1970;168:1–81.
[20]
Jackson HH, Glasgow RE, Mulvihill SJ, Cannon-Albright LA. Familial risk in gallbladder cancer. J Am Coll Surg. 2007;(205):S38–S138.
[21]
Socea, Bogdan, Diaconu, Camelia C, Bratu, Ovidiu Gabriel, Neagu, Tiberiu Paul, Badiu, Cristinel D., Busoi, Grigore, Constantin, Vlad D. Benefits of surgical intervention in locally advanced breast cancer - a Lynch II case presentation. Romanian Medical Journal, 2018, LXV (4): 253-5.