DIFFERENTIAL DIAGNOSIS BETWEEN COLONIC CROHN`S DISEASE AND ULCERATIVE PANCOLITIS – ENDOSCOPIC AND HISTOLOGIC CRITERIA
Accepted
28 March 2026
Available Online
15 March 2016
Abstract
THE PURPOSE OF THIS PAPER IS TO CLARIFY THE PARAMETERS USED FOR A DIFFERENTIAL DIAGNOSIS BETWEEN CROHN`S COLITIS AND ULCERATIVE PANCOLITIS AND TO IDENTIFY THOSE WITH THE HIGHEST DIAGNOSTIC VALUE. THE IMPORTANCE OF THE STUDY WILL BE REFLECTED IN LOWER RATES OF DIAGNOSIS DELAY, LOWER RATE OF LONGTERM COMPLICATIONS AND INTO A BETTER THERAPEUTIC APPROACH. THIS IS A RETROSPECTIVE STUDY, WHICH WAS PERFORMED ON 54 PATIENTS DIAGNOSED WITH CROHN`S COLITIS OR ULCERATIVE PANCOLITIS, WHO WERE ANALYZED EPIDEMIOLOGICALL Y AND PHENOTYPICALLY. THEY WERE DIVIDED IN 2 GROUPS AND COMPARED BASED ON THE ENDOSCOPICAL AND HISTOLOGICAL CHARACTERISTICS. THE ENDOSCOPIC LESIONS WITH THE HIGHEST DIAGNOSTIC VALUE FOR CROHN`S WERE FOUND TO BE THE LONGITUDINAL AND DEEP ULCERS, AND ALSO, HIGHER SEVERITY OF LESIONS THE ON THE RIGHT COLON. AS FOR ULCERATIVE PANCOLITIS HISTOPATHOLOGICAL CHARACTERISTICS WITH THE HIGHEST DIAGNOSTIC VALUE WERE FOUND TO BE THE ASSIMTERICAL AN DIFFUSE DISTRIBUTION OF ARCHITECTURAL CHANGES, CRIPTITIS AND CRYPTIC AB SCESSES. THE EPITHELIOID GRANULOMA, ONCE CONSIDERED GOLD STANDARD FOR A DIAGNOSIS OF CROHN`S DISEASE IS RARELY ENCOUNTERED ON THE TISSUE SAMPLES FROM COLONIC BIOPSIES. BASAL PLASMOCITOSIS IS PRESENT IN BOTH DISEASES, BEING A MARKER OF CHRONIC COLITIS AND HAVING NO SPECIFICITY FOR CROHN`S OR ULCERATIVE COLITIS.
Keywords
CROHN`S DISEASE
ULCERATIVE PANCOLITIS
CHRONIC INFLAMMATORY COLITIS
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