RISK FACTORS IN PANCREATIC CANCER

PREVIOUS STUDIES HAVE SHOWN A VARIETY OF RISK FACTORS THAT MAY BE INVOLVED IN THE AETIOLOGY OF PANCREATIC NEOPLASIA. WE EXAMINED RISK FACTORS FOR PANCREATIC CANCER IN A CASE–CONTROL STUDY CONDUCTED IN FUNDENI CLINICAL INSTITUTE BETWEEN SEPTEMBER 2016 AND SEPTEMBER 2018, THAT INCLUDED 74 INCIDENT CASES AND 74 CONTROLS ADMITTED FOR NON - NEOPLASTIC DISEASES, FREQUENCY -MATCHED TO CASES BY SEX AND AGE. LOGISTIC REGRESSION MODELS WERE USED FOR MULTIVARIATE OR SUCH AS SEX, AGE, DIABETES, VIRAL HEPATITIS, SMOKING AND ALCOHOL CONSUMPTION STATUS, AND OTHER PERSONAL AND FAMILIAL HISTORY. OUR FINDINGS SUPPORT PREVIOUS STUDIES INDICATING THAT DIABETES IS A RISK FACTOR FOR PANCREATIC CANCER (OR 4.8, P<0.05). CHOLECYSTECTOMY ALSO APPEARED TO BE A RISK FACTOR, SUBJECTS WITH A CHOLECYSTECTOMY AT LEAST 20 YEARS PRIOR TO THE DIAGNOSIS OF PANCREATIC CANCER EXPERIENCED AN INCREASED RISK, WHICH WAS MARGINALLY SIGNIFICANT. IN CONTRAST, SIGNIFICANT 2- FOLD (P<0.05) REDUCED RISK WAS ASSOCIATED WITH ALLERGIES. IN ADDITION, WE OBSERVED SIGNIFICANTLY INCREASED RISKS FOR SUBJECTS WHO SMOKED OR ARE CURRENTLY SMOKING. THIS STUDY DEMONSTRATES THE ROLE AS RISK FACTORS OF SOME ENVIRONMENTAL FACTORS, PERSONAL AND FAMILIAL HISTORY, BUT THESE ASSOCIATIONS, HOWEVER, MAY BE DUE TO CHANCE SINCE THE NUMBER OF INDIVIDUALS INCLUDED IN THE STUDY IS REDUCED.

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