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Research Articles Issue 2 · 2020 · pp. 139–146 · Issue page

HYPOTHYROIDISM-A RISK FACTOR FOR THE NON-ALCOHOLIC FATTY LIVER DISEASE

MI
Mihaela POPESCU1
IU
Iulian Alin POPESCU2
DA
Daniela NEAGOE3
AL
Alice GHENEA4
OA
Oana IANA5
VL
Vlad Dumitru BÃLEANU6
AN
Anca UNGUREANU7
GE
Georgiana UNGUREANU8
1 Clinical Municipal Hospital Filantropia, Craiova; University of Medicine and Pharmacy, Craiova
2 Clinical Municipal Hospital Filantropia, Craiova; University of Medicine and Pharmacy, Craiova
3 Clinical Emergency County Hospital, Craiova; University of Medicine and Pharmacy, Craiova
4 Clinical Emergency County Hospital, Craiova; University of Medicine and Pharmacy, Craiova
5 C.I. Parhon National Institute of Endocrinology Bucharest Romania
6 "Sf. Pantelimon" Emergency Clinical Hospital, General Surgery Department, 340 Sos. Pantelimon, 021659, Bucharest, Romania
7 Clinical Emergency County Hospital, Craiova; University of Medicine and Pharmacy, Craiova
8 Clinical Municipal Hospital Filantropia, Craiova
Corresponding author: [email protected]
DOI https://doi.org/10.38173/RST.2020.20.2.13:139-146
Received 15 September 2020
Revised -
Accepted 05 October 2020
Available Online 15 November 2020
Abstract
INTRODUCTION. THYROID DYSFUNCTION IS A COMMON CONDITION THAT AFFECTS LIFELONG HEALTH. BECAUSE THETHYROID HORMONES PLAY A FUNDAMENTAL ROLE IN LIPID METABOLISM, HYPOTHYROIDISM MAY CAUSE HYPERCHOLESTEROLEMIA AND PLAY AN ESSENTIAL ROLE IN THE PATHOGENESIS OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD). MATERIAL, METHOD. THE AIM OF THIS STUDY WAS TO CHARACTERIZE THE RELATIONSHIP BETWEEN THE BROAD SPECTRUM OF HYPOTHYROIDISM AND THE NON -ALCOHOLIC FATTY LIVER DISEASE. THE STUDY GROUP CONSISTED OF 124 PATIENTS WITH THYROID DYSFUNCTION-SUBCLINICAL OR MANIFEST HYPOTHYROIDISM. CONTROLS WITH NORMAL-RANGE TSH LEVELS AND FT4 LEVELS WERE RANDOMLY MATCHED TO THE CASES BY AGE AND SEX. THE MEAN AGE OF THE SUBJECTS WAS 41.5 (SD 11.5) YEARS, RANGING FROM 18 TO 72 YEARS OLD. RESULTS, DISCUSSION. THE PREVALENCE OF NAFLD IN THE STUDY GROUP WAS 35.4%, WITH A POSITIVE DIAGNOSIS OF 40.9% AND 59.09% IN MEN AND WOMEN, RESPECTIVELY. NAFLD AND METABOLIC SYNDROME WERE STATISTICALLY SIGNIFICANTLY ASSOCIATED WITH HYPOTHYROIDISM (18.5% VS. 35.4% AND 17.74% VS. 31.4%, P<0.001, RESPECTIVELY). THE PREVALENCE OF NAFLD WITH ELEVATED ALT WAS SIGNIFICANTLY HIGHER IN THE SUBJECTS WITH HYPOTHYROIDISM (11.29% VS. 7.25%, P<0.01). CONCLUSIONS. THE HYPOTHYROIDISM IS ASSOCIATED WITH NAFLD AND MAY BE CONSIDERED A RISK FACTOR FOR THIS DISORDER. THERE IS A RELEVANT CLINICAL RELATIONSHIP BETWEEN THESE TWO DISEASES.
Keywords
HYPOTHYROIDISM NON -ALCOHOLIC FATTY LIVER DISEASE METABOLIC
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