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Research Articles Supplement 2 · 2019 · pp. 158–171 · Issue page

RESHAPING PURPOSE – USE OF METFORMIN IN ENDOMETRIOSIS AN APPROACH TO RECENT LITERATURE

LA
Lavinia IFTENE1
CL
Claudia MEHEDINTU2
EL
Elvira BRATILA3
FR
Francesca FRINCU4
DI
Diana MIHAI5
GA
Gabriela IONESCU6
OV
Ovidiu Gabriel BRATU7
BO
Bogdan SOCEA8
AN
Ana-Maria-Emanuela CAZACHEVICI9
1 Department of Obstetrics and Gynecology, Clinical Hospital ”Nicolae Malaxa” Bucharest, Romania, ”Carol Davila” University of Medicine and Pharmacy Bucharest
2 Department of Obstetrics and Gynecology, Clinical Hospital ”Nicolae Malaxa” Bucharest, Romania, ”Carol Davila” University of Medicine and Pharmacy Bucharest
3 Department of Obstetrics and Gynecology, ”Prof. Dr. Panait Sârbu” Obstetrics and Gynecology Clinical Hospital, ”Carol Davila” University of Medicine and Pharmacy Bucharest
4 Department of Obstetrics and Gynecology, Clinical Hospital ”Nicolae Malaxa” Bucharest, Romania, ”Carol Davila” University of Medicine and Pharmacy Bucharest
5 Department of Obstetrics and Gynecology, ”Prof. Dr. Panait Sârbu” Obstetrics and Gynecology Clinical Hospital, ”Carol Davila” University of Medicine and Pharmacy Bucharest
6 Department of Obstetrics and Gynecology, Clinical Hospital ”Nicolae Malaxa” Bucharest, Romania, ”Carol Davila” University of Medicine and Pharmacy Bucharest
7 Department of Urology, ”Carol Davila” University of Medicine andPharmacyBucharest, Carol Davila University Central Emergency Military Hospital
8 Department of General Surgery "Sf. Pantelimon" Emergency Clinical Hospital Bucharest
9 Department of Obstetrics and Gynecology, Clinical Hospital ”Nicolae Malaxa” Bucharest, Romania, ”Carol Davila” University of Medicine and Pharmacy Bucharest
Accepted 29 March 2026
Available Online 20 July 2019
Abstract
ENDOMETRIOSIS CAN BE CLASSICALLY DEFINED AS THE PRESENCE OF A FUNCTIONAL ENDOMETRIAL LAYER WITH ENDOMETRIAL GLANDS OUTSIDE THE UTERINE CAVITY, INDUCING A CHRONIC, INFLAMMATORY REACTION, LINKED TO CHRONIC PELVIC PAIN AS WELL AS FERTILITY ISSUES. A LARGE AMOUNT OF LITERATURE SURVEYS AS WELL AS CURRENT STUDIES RECKON ENDOMETRIOSIS AS THE RESULT OF A DEFECTIVE IMMUNOSURVEILLANCE CASCADE IN FERTILE WOMEN, SUGGESTING THAT THE CONSTANT PERITONEAL INFLAMMATORY ENVIRONMENT STIMULATES PROGRESS AS WELL AS MAINTENANCE OF THE DISEASE. THEREFORE, NOVEL THERAPEUTICAL APPROACHES ARE NEEDED IN ORDER TO TARGET DIFFERENT PATHOGENIC SPECTRUMS. METFORMIN, A WIDELY USED BIGUANIDE IMPROVING INSULIN SENSITIVITY IN DIABETES, CAN ALSO PROVIDE BOTH ANTI-INFLAMMATORY PROPERTIES AS WELL AS A MODULATORY EFFECT ON OVARIAN STEROID PRODUCTION, TWO ACTIONS THAT HAVE BEEN SUGGESTED TO OFFER NEW PERSPECTIVES IN ENDOMETRIOSIS THERAPY. MANAGING ENDOMETRIOSIS REQUIRES TARGETING A COMPLEX NETWORK OF LOCALLY PRODUCED CYTOKINES MODULATING THE GROWTH AND INFLAMMATORY BEHAVIOR OF ECTOPIC ENDOMETRIAL IMPLANTS. THEREFORE, WHAT WE DEFINE AS THE MAIN OBJECTIVES OF THIS LITERATURE REVIEW BECOME AS FOLLOWING: TO ASSESS WHETHER METFORMIN MAY BE EFFECTIVE AS A NOVEL APPROACH FOR ENDOMETRIOSIS, DOSE-DEPENDENTLY OR NOT, AS WELL AS TO EVALUATE THE EFFECTS OF THIS AGENT ON INFLAMMATORY RESPONSES, ESTRADIOL PRODUCTION AND NEVERTHELESS ENDOMETRIOTIC STROMAL CELLS PROLIFERATION IN BOTH IN VITRO AND IN VIVO CONDITIONS.
Keywords
ENDOMETRIOSIS METFORMIN IL-8 IL-6 IMMUNOSURVEILLANCE VEGF
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